玄米と米糠（胚芽・表皮）を麹菌で発酵させた食品FBRA（ふぶら）の学術研究 メディア掲載一覧・論文一覧
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- 玄米酵素学術顧問 小林博先生
- （医学博士、公益財団法人札幌がんセミナー相談役、北海道大学名誉教授、元日本癌学会会長）
元々は株式会社玄米酵素創業者の岩崎さんとロータリークラブでご縁をいただき、気脈の通じるものがあり、学術研究をお手伝いするようになりました。
FBRA（ふぶら）が世の中から信用、信頼されるためには、医学的な証明が絶対必要だという私の提言を受け止めてくれ、1998年に研究会が発足しました。
それ以来、各方面の専門家に依頼し、厳しい目で研究を続けています。
動物実験ながら多方面にわたり医学的に興味深い研究結果が出てきており、国際的に権威ある専門誌に英文論文が既に20本以上も掲載されるまでになりました。
※以下の英文は、論文タイトル・著者（Author）・投稿雑誌名（Source）の順で紹介しています。
FBRA（ふぶら）の学術研究 論文一覧
2023年
Stable Isotope Dilution LC/ESI-SRM/MS Analysis for Highly Polar Bioactive Dipeptides Found in Fermented Brown Rice Product using a Porous Graphitic Carbon Column
- Author(s)
- Ono S., Hatakawa Y., Lee S.H. and Oe T.
- Source
- Food Anal. Meth., 16, 1596–1605 (2023).
Determination of L-Carnitine and Acetyl-L-carnitine in Aspergillus oryzae- Fermented Rice Bran Product by Hydrophobic Derivatization–LC/ESI-MS/MS
- Author(s)
- Hagiwara Y., Ishimaru A., Horie Y., Itoh M., Ikegawa S., and Higashi T.
- Source
- Chromatography, 44, 95-103 (2023).
2022年
Analytical evaluation of fatty acid esters of hydroxy fatty acid quantity in fermented brown rice and rice bran (FRBA)
- Author(s)
- Watanabe A., Balas L., Saigusa D., Ogura J., Durand T., Mano N., and Yamaguchi H.
- Source
- Food Chem. Adv., 1, 100040 (2022).
Prevention of tumor progression in inflammation-related carcinogenesis by anti-inflammatory and anti-mutagenic effects brought about by ingesting fermented brown rice and rice bran with Aspergillus oryzae (FBRA)
- Author(s)
- Nemoto H., Otake M., Matsumoto T., Izutsu R., Jehung J.P., Goto K., Osaki M., Mayama M., Shikanai M., Kobayashi H., Watanabe T., and Okada F.
- Source
- J. Funct. Foods, 88, 104907 (2022).
2021年
Aspergillus oryzae Fermented Brown Rice and Bran Supplement “FBRA” for Health and Cancer Prevention
- Author(s)
- Shaw Watanabe, Kohta Kikuchi, Shoichi Mizuno and Tomomitsu Mizuno
- Source
- Acta Scientific NUTRITIONAL HEALTH 5.12 (2021): 20-32.
Anti-inflammatory effect of fermented brownrice and rice bran with Aspergillus oryzae on mice
- Author(s)
- Umeyama, L., Kasahara, S., Sugawara, M., Yokoyama, S., Saiki, I., and Hayakawa, Y.
- Source
- Tradit. Kampo Med., 8, 60-65 (2021).
Preventive effect of fermented brown rice and rice bran on spontaneous type 1 diabetes in NOD female mice
- Author(s)
- Kataoka, k., Nemoto, H., Sakurai, A., Yasutomo, K., and Shikanai, M.
- Source
- J. Funct. Foods,78, 104356 (2021).
2020年
Analysis of steryl glucosides in rice bran-based fermented food by LC/ESI-MS/MS
- Author(s)
- Murai, T., Jin, S., Itoh, M., Horie, Y., Higashi, T., and Ikegawa, S.
- Source
- Steroids,158, 108605 (2020).
Quantification of ergothioneine in Aspergillus oryzae-fermented rice bran by a newly-developed LC/ESI-MS/MS method
- Author(s)
- Horie, Y., Goto, A., Imamura, R., Itoh, M., Ikegawa, S., Ogawa, S., and Higashi, T.
- Source
- LWT,118, 108812 (2020).
Fermented brown rice and rice bran with Aspergillus oryzae as a new promising agent for cancer prevention
- Author(s)
- Mori, H.
- Source
- Am. J. Biomed. Sci. & Res.,6, 232-233 (2019).
2019年
1H-NMRメタボローム解析を用いた玄米米糠麹の品質評価
- Author(s)
- 堀江裕紀子、根本英幸、藤田仁、池川繁男、熊木靖康裕、大西裕季、久米田博之、出村誠、相沢智康
- Source
- 日本食品科学工学会誌,66, 139-146 (2019).
Changes in polyamine content in rice bran due to fermentation with Aspergillus oryzae analyzed by LC/ESI-MS/MS combined with derivatization
- Author(s)
- Horie, Y., Goto, A., Tsubuku, S., Itoh, M., Ikegawa, S., Ogawa, S., and Higashi, T.
- Source
- Anal. Sci.,35, 427-432 (2019).
2018年
Preventive effects of fermented brown rice and rice bran on spontaneous lymphomagenesis in AKR/NSlc female mice
- Author(s)
- Kuno, T., Kato, H., Naiki-Ito, A., Suzuki, S., Tanaka, T., Takahashi, S., and Mori, H.
- Source
- Asian Pac. J. Cancer Prev., 19, 3217-3223 (2018).
2017年
Isotope-coded derivatization based LC/ESI-MS/MS methods using a pair of novel reagents for quantification of hydroxycinnamic acids and hydroxybenzoic acids in fermented brown rice product
- Author(s)
- Ogawa, S., Takafuji, K., Tsubuku, S., Horie, Y., Ikegawa, S., and Higashi, T.
- Source
- J. Pharm. Biomed. Anal., 142, 162-170 (2017).
Fermented brown rice extract stimulates BDNF gene transcription in C6 glioma cells: possible connection with HO-1 expression
- Author(s)
- Morita, K., Nishibori, N., Kishibuchi, R., Itoh, M., Horie, Y., and Nemoto, H.
- Source
- J. Diet. Suppl., 14, 214-228 (2017).
Analysis of volatile constituents in fermented brown rice and rice bran by Aspergillus oryzae (FBRA)
- Author(s)
- Tanaka, K., Horie, Y., Nemoto, H., Kosaka, H., Jo, M., and Tezuka, Y.
- Source
- J. Comput. Aided Chem., 18, 42-45 (2017).
Analysis of water-soluble constituents in fermented brown rice and rice bran by Aspergillus oryzae (FBRA)
- Author(s)
- Tanaka, K., Horie, Y., Nemoto, H., Kosaka, H., Jo, M., and Tezuka, Y.
- Source
- J. Comput. Aided Chem., 18, 46-50 (2017).
2016年
Fermented brown rice extract causes apoptotic death of human acute lymphoblastic leukemia cells via death receptor pathway
- Author(s)
- Horie, Y., Nemoto, H., Itoh, M., Kosaka, H., and Morita, K.
- Source
- Appl. Biochem. Biotechnol., 178, 1599–1611 (2016).
Preventive effects of fermented brown rice and rice bran against prostate carcinogenesis in TRAP rats
- Author(s)
- Kuno, T., Nagano, A., Mori, Y., Kato, H., Nagayasu, Y., Naiki-Ito, A., Suzuki, S., Mori, H., and Takahashi, S.
- Source
- Nutrients, 8, 421-431 (2016).
2015年
Fermented brown rice and rice bran with Aspergillus oryzae (FBRA) prevents inflammation-related carcinogenesis in mice, through inhibition of inflammatory cell infiltration
- Author(s)
- Onuma, K., Kanda, Y., Suzuki Ikeda, S., Sakaki, R., Nonomura, T., Kobayashi, M., Osaki, M., Shikanai, M., Kobayashi, H., and Okada, F.
- Source
- Nutrients, 7, 10237-10250 (2015).
Preventive effects of fermented brown rice and rice bran against N-nitrosobis(2-oxopropyl) amine-induced pancreatic tumorigenesis in male hamsters
- Author(s)
- Kuno, T., Takahashi, S., Tomita, H., Hisamatsu, K., Hara, A., Hirata, A., Kobayashi, H., and Mori, H.
- Source
- Oncol. Lett., 10, 3377-3384 (2015).
2013年
Angiotensin-I converting enzyme (ACE) inhibitory activity of aqueous extract prepared from fermented brown rice: A potential functional food for management of hypertension
- Author(s)
- Nishibori, N., Kishibuchi, R., Sagara, T., Itoh, M., Horie, Y., and Morita, K.
- Source
- Phytopharmacology, 4, 237-245 (2013).
2012年
Extract of fermented brown rice induces apoptosis of human colorectal tumor cells by activating mitochondrial pathway
- Author(s)
- Itoh, M., Nishibori, N., Sagara, T., Horie, Y., Motojima, A., and Morita, K.
- Source
- Phytother. Res., 26, 1661-1666 (2012).
2011年
Effects of fermented brown rice on the intestinal environments in healthy adult
- Author(s)
- Nemoto, H., Ikata, K., Arimochi, H., Iwasaki, T., Ohnishi, Y., Kuwahara, T., and Kataoka, K.
- Source
- J. Med. Invest., 58, 235-245 (2011).
2010年
Chemopreventive effect of fermented brown rice and rice bran (FBRA) on the inflammation-related colorectal carcinogenesis in ApcMin/+ mice
- Author(s)
- Phutthaphadoong, S., Yamada, Y., Hirata, A., Tomita, H., Hara, A., Limtrakul, P., Iwasaki, T., Kobayashi, H., and Mori, H.
- Source
- Oncol. Rep., 23, 53-59 (2010).
2009年
Chemopreventive effects of fermented brown rice and rice bran against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in female A/J mice
- Author(s)
- Phutthaphadoong, S., Yamada, Y., Hirata, A., Tomita, H., Taguchi, A., Hara, A., Limtrakul, P. N., Iwasaki, T., Kobayashi, H., and Mori, H.
- Source
- Oncol. Rep., 21, 321-327 (2009).
Promotive excretion of causative agents of Yusho by intake of fermented brown rice with Aspergillus oryze in patients with Yusho -with regard to PCDFs and PCDDs-
- Author(s)
- Nagayama, J., Hirakawa, H., Kajiwara, J., Iida, T., Todaka, T., Uenotsuchi, T., Shibata, S., Tsuji, H., and Iwasaki, T.
- Source
- Fukuoka Igaku Zasshi, 100, 192-199 (2009).
2008年
Inhibitory effects of fermented brown rice on induction of acute colitis by dextran sulfate sodium in rats
- Author(s)
- Kataoka, K., Ogasa, S., Kuwahara, T., Bando, Y., Hagiwara, M., Arimochi, H., Nakanishi, S., Iwasaki, T., and Ohnishi, Y.
- Source
- Dig. Dis. Sci., 53, 1601-1608 (2008).
Preventive effect of fermented brown rice and rice bran on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats
- Author(s)
- Tomita, H., Kuno, T., Yamada, Y., Oyama, T., Asano, N., Miyazaki, Y., Baba, S., Taguchi, A., Hara, A., Iwasaki, T., Kobayashi, H., and Mori, H.
- Source
- Oncol. Rep., 19, 11-15 (2008).
2007年
Modifying effects of fermented brown rice on fecal microbiota in rats
- Author(s)
- Kataoka, K., Kibe, R., Kuwahara, T., Hagiwara, M., Arimochi, H., Iwasaki, T., Benno, Y., and Ohnishi, Y.
- Source
- Anaerobe, 13, 220-227 (2007).
Chemopreventive effect of fermented brown rice and rice bran on 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats
- Author(s)
- Long, N. K., Makita, H., Yamashita, T., Toida, M., Kato, K., Hatakeyama, D., and Shibata, T.
- Source
- Oncol. Rep. 17, 879-885 (2007).
Excretion of causative PCDFs congeners of Yusho by one year intake of FBRA in patients with Yusho
- Author(s)
- Nagayama, J., Hirakawa, H., Kajiwara, J., Iida, T., Todaka, T., Uenotsuchi, T., Shibata, S., Tsuji, H., and Iwasaki, T.
- Source
- Fukuoka Igaku Zasshi, 98, 215-221 (2007).
2006年
Chemoprevention of mouse urinary bladder carcinogenesis by fermented brown rice and rice bran
- Author(s)
- Kuno, T., Hirose, Y., Yamada, Y., Hata, K., Qiang, S. H., Asano, N., Oyama, T., Zhi, H., Iwasaki, T., Kobayashi, H., and Mori, H.
- Source
- Oncol. Rep., 15, 533-538 (2006).
Antimetastatic and immunostimulatory properties of fermented brown rice
- Author(s)
- Sakurai, H., CHOO, M. K., Chino, A., Tega, E., Iwasaki, T. Kobayashi, H., and Saiki, I.
- Source
- J. Trad. Med., 23, 112-116 (2006).
Inhibitory effects of fermented brown rice and rice bran on the development of acute hepatitis in Long-Evans Cinnamon rats
- Author(s)
- Shibata, T., Nagayasu, H., Kitajo, H., Arisue, M., Yamashita, T., Hatakeyama, D., Iwasaki, T., and Kobayashi, H.
- Source
- Oncol. Rep., 15, 869-874 (2006).
2005年
Promotive excretion of causative agents of Yusho by one year intake of FBRA in Japanese people
- Author(s)
- Nagayama, J., Takasuga, T., Tsuji, H., and Iwasaki, T.
- Source
- Fukuoka Igaku Zasshi, 96, 241-248 (2005).
2004年
Preventive effect of fermented brown rice and rice bran on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in rats
- Author(s)
- Kuno, T., Hirose, Y., Hata, K., Kato, K., Qiang, S. H., Kitaori, N., Hara, A., Iwasaki, T., Yoshimura, T., Wada, K., Kobayashi, H., and Mori, H.
- Source
- Int. J. Oncol., 25, 1809-1815 (2004).
2003年
Preventive effect of fermented brown rice and rice bran on diethylnitrosoamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats
- Author(s)
- Katayama, M., Sugie, S., Yoshimi, N., Yamada, Y., Sakata, K., Qiao, Z., Iwasaki, T., Kobayashi, H., and Mori, H.
- Source
- Oncol. Rep., 10, 875-880 (2003).
Active elimination of causative PCDFs／DDs congeners of Yusho by one year intake of FBRA in Japanese people
- Author(s)
- Nagayama J, Takasuga T, Tsuji H, Umehara M, Sada T, Iwasaki T.
- Source
- Fukuoka Igaku Zasshi, 94, 118-125 (2003).
2002年
Preventive effect of fermented brown rice and rice bran against colon carcinogenesis in male F344 rats
- Author(s)
- Katyama, M., Yoshimi, N., Yamada, Y., Sakata, K., Kuno, T., Yoshida, K., Qiao, Z., Vihn, P. Q., Iwasaki, T., Kobayashi, H., and Mori, H.
- Source
- Oncol. Rep., 9, 817-822 (2002).
FBRA（ふぶら）研究会の主なメンバー
株式会社玄米酵素では、平成10年にFBRA（ふぶら）学術研究会を発足、学術的な研究を全国各地の大学にお願いしています。
主なメンバーの紹介
- 小林 博 先生
- 北海道大学名誉教授（元日本癌学会会長）
- 田澤 賢次 先生
- 富山医科薬科大学名誉教授
- 森 秀樹 先生
- 岐阜大学名誉教授
- 大西 克成 先生
- 徳島大学名誉教授
- 済木 育夫 先生
- 富山大学名誉教授
- 岡田 太 先生
- 鳥取大学医学部教授
- 石川 秀樹 先生
- 京都府立医科大学特任教授
- 片岡 佳子 先生
- 徳島大学大学院教授
